This is Part 1 of a talk by Sheldrake at the conference Electric Universe 2013: The Tipping Point, in Albuquerque, New Mexico. Many scientists like to think that science already understands the ways of the natural world. The fundamental questions are answered, leaving only the details to be filled in. The impressive achievements of science seemed to support this confident attitude. But recent research has revealed unexpected problems at the heart of physics, cosmology, biology, medicine and psychology.